Introduction to dynamic treatment strategies and sequential multiple assignment randomization

Sequential multiple assignment randomization trials with enrichment design.

Sequential multiple assignment randomization trial (SMART) is a powerful design to study Dynamic Treatment Regimes (DTRs) and allows causal comparisons of DTRs. To handle practical challenges of SMART, we propose a SMART with Enrichment (SMARTER) design, which performs stage-wise enrichment for SMART. SMARTER can improve design efficiency, shorten the recruitment period, and partially reduce tr...

Optimization of behavioral dynamic treatment regimens based on the sequential, multiple assignment, randomized trial (SMART).

BACKGROUND AND PURPOSE A behavioral intervention is a program aimed at modifying behavior for the purpose of treating or preventing disease, promoting health, and/or enhancing well-being. Many behavioral interventions are dynamic treatment regimens, that is, sequential, individualized multicomponent interventions in which the intensity and/or type of treatment is varied in response to the needs...

Using Sequential, Multiple Assignment, Randomized Trial (SMART) Designs to Build Individualized Treatment Sequences

Use of personalized Dynamic Treatment Regimes (DTRs) and Sequential Multiple Assignment Randomized Trials (SMARTs) in mental health studies

Dynamic treatment regimens (DTRs) are sequential decision rules tailored at each point where a clinical decision is made based on each patient's time-varying characteristics and intermediate outcomes observed at earlier points in time. The complexity, patient heterogeneity, and chronicity of mental disorders call for learning optimal DTRs to dynamically adapt treatment to an individual's respon...

Randomization and Restart Strategies

The running time for solving constraint satisfaction problems (CSP) and propositional satisfiability problems (SAT) using systematic backtracking search has been shown to exhibit great variability. Randomization and restarts is an effective technique for reducing such variability to achieve better expected performance. Several restart strategies have been proposed and studied in previous work a...